Ser175
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Home > Phosphorylation Site Page: > Ser175  -  ATP6V1A (mouse)

Site Information
LPPRNRGsVTYIAPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14913505

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:
kidney cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 ) , PKACA (human) ( 3 )
Kinases, in vitro:
AurA (human) ( 1 ) , PKACA (human) ( 3 )
Treatments:
6-MB-cAMP ( 3 ) , IBMX ( 3 ) , mPKI ( 3 )

Downstream Regulation
Effects of modification on ATP6V1A:
enzymatic activity, induced ( 1 , 3 ) , intracellular localization ( 1 , 3 )
Effects of modification on biological processes:
cell motility, induced ( 1 )

References 

1

Al-Bataineh MM, et al. (2016) Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol 310, F1216-28
26911844   Curated Info

2

Alzamora R, et al. (2013) AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol 305, F943-56
23863464   Curated Info

3

Alzamora R, et al. (2010) PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem 285, 24676-85
20525692   Curated Info