Ser70

Site Information
QtsGLsPsRLsksQG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 14913502

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Disease tissue studied:	breast cancer ( 1 ) , breast ductal carcinoma ( 1 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:	breast ( 1 ) , Calu 6 (pulmonary) ( 3 ) , HeLa (cervical) ( 4 ) , HOP62 (pulmonary) ( 3 ) , NB10 (neural crest) ( 2 ) , NCI-H1648 (pulmonary) ( 3 ) , NCI-H322 (pulmonary) ( 3 ) , NPC (neural crest) ( 2 )

Upstream Regulation
Treatments:	MMS ( 4 )

References
1	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
2	DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513 24349301 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Michels AA, et al. (2010) mTORC1 directly phosphorylates and regulates human MAF1. Mol Cell Biol 30, 3749-57 20516213 Curated Info