Ser42
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Home > Phosphorylation Site Page: > Ser42  -  TWIST1 (human)

Site Information
GGRkRRSsRRsAGGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14821304

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , breast ( 2 ) , colon ( 2 ) , HEK293T (epithelial) ( 1 ) , lung ( 2 ) , MCF-7 (breast cell) ( 2 ) , MDA-MB-231 (breast cell) ( 1 ) , prostate ( 2 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 , 2 )
Kinases, in vitro:
Akt1 (human) ( 1 , 2 )
Treatments:
ionizing_radiation ( 2 ) , LY294002 ( 2 ) , serum ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on TWIST1:
protein degradation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , carcinogenesis, induced ( 2 )

References 

1

Li CW, et al. (2016) AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res 76, 1451-62
26759241   Curated Info

2

Vichalkovski A, et al. (2010) PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage. Oncogene 29, 3554-65
20400976   Curated Info