Ser123
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Home > Phosphorylation Site Page: > Ser123  -  TWIST1 (human)

Site Information
RERQRtQsLNEAFAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14821303

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 2 , 3 )
Treatments:
colforsin ( 3 )

Downstream Regulation
Effects of modification on TWIST1:
molecular association, regulation ( 1 ) , protein degradation ( 2 )
Induce interaction with:
TWIST1 (human) ( 1 )
Inhibit interaction with:
TCF12 (human) ( 1 )

References 

1

Fan X, et al. (2020) TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation. Mol Cell Biol
32179550   Curated Info

2

Li CW, et al. (2016) AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res 76, 1451-62
26759241   Curated Info

3

Vichalkovski A, et al. (2010) PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage. Oncogene 29, 3554-65
20400976   Curated Info