Ser1891
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Home > Phosphorylation Site Page: > Ser1891  -  ATM (human)

Site Information
TtPANLDsEsEHFFR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14735942

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 , 5 , 6 , 9 ) , phospho-antibody ( 2 , 8 ) , western blotting ( 8 )
Disease tissue studied:
HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, triple negative ( 3 ) , eye cancer ( 8 ) , lung cancer ( 6 ) , non-small cell lung cancer ( 6 ) , ovarian cancer ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATM (human) ( 8 ) , C9orf72 (human) ( 2 )
Treatments:
ionizing_radiation ( 4 , 9 ) , KU-55933 ( 8 ) , nutlin-3 ( 8 ) , RITA ( 8 ) , topotecan ( 8 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, inhibited ( 8 )

References 

1

Ohba S, et al. (2020) Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity. Cell Rep
32294440   Curated Info

2

Walker C, et al. (2017) C9orf72 expansion disrupts ATM-mediated chromosomal break repair. Nat Neurosci 20, 1225-1235
28714954   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Lee HJ, et al. (2015) Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25, 225-36
25601159   Curated Info

5

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

6

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

7

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

8

de Lange J, et al. (2012) Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene 31, 1105-16
21765463   Curated Info

9

Bennetzen MV, et al. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 9, 1314-23
20164059   Curated Info