Ser1197

Site Information
HIQTPMLsQEQAQPP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 452030

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	'muscle, smooth' ( 1 ) , 293 (epithelial) [NFAT5 (human)] ( 2 ) , vascular ( 1 )

Upstream Regulation
Putative in vivo kinases:	ATM (human) ( 2 )
Treatments:	hypertonic_buffer ( 2 )

References
1	Zappe M, et al. (2018) NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol 9, 1190 30190682 Curated Info
2	Irarrazabal CE, Liu JC, Burg MB, Ferraris JD (2004) ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A 101, 8809-14 15173573 Curated Info