Ser106
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Home > Phosphorylation Site Page: > Ser106  -  p300 (human)

Site Information
GPGQVMAsQAQQSSP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14652802

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , immunoprecipitation ( 2 , 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
ataxia-telangiectasia ( 2 ) , bone cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 2 , 3 )
Kinases, in vitro:
ATM (human) ( 3 )
Treatments:
etoposide ( 3 ) , ionizing_radiation ( 2 , 3 )

Downstream Regulation
Effects of modification on p300:
acetylation ( 2 ) , enzymatic activity, induced ( 2 ) , molecular association, regulation ( 2 ) , protein stabilization ( 3 )
Induce interaction with:
NBS1 (human) ( 2 )

References 

1

Yasuda T, et al. (2018) Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites. PLoS Genet 14, e1007277
29590107   Curated Info

2

Jang ER, Choi JD, Lee JS (2011) Acetyltransferase p300 regulates NBS1-mediated DNA damage response. FEBS Lett 585, 47-52
21108945   Curated Info

3

Jang ER, Choi JD, Jeong G, Lee JS (2010) Phosphorylation of p300 by ATM controls the stability of NBS1. Biochem Biophys Res Commun 397, 637-43
20471956   Curated Info