Ser348
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Home > Phosphorylation Site Page: > Ser348  -  SQSTM1 (rat)

Site Information
SSKEVDPsTGELQsL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14580829

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 2 ) , HEK293T (epithelial) ( 2 )

Upstream Regulation
Regulatory protein:
LRRK2 (human) ( 2 )
Treatments:
MG132 ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on SQSTM1:
molecular association, regulation ( 2 )
Induce interaction with:
KEAP1 (rat) ( 2 )

References 

1

Hu S, et al. (2021) The therapeutic effect of TBK1 in intervertebral disc degeneration via coordinating selective autophagy and autophagic functions. J Adv Res 30, 1-13
34026282   Curated Info

2

Park S, et al. (2016) Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS One 11, e0163029
27631370   Curated Info

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