Thr233
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Home > Phosphorylation Site Page: > Thr233  -  APE1 (human)

Site Information
NKkNAGFtPQERQGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14645304

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , E.coli (bacterial) ( 1 ) , HCT116 (intestinal) ( 1 ) , MEF (fibroblast) ( 1 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 1 )

Downstream Regulation
Effects of modification on APE1:
activity, induced ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Busso CS, Wedgeworth CM, Izumi T (2011) Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res 39, 8017-28
21727086   Curated Info

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