Thr490
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Home > Phosphorylation Site Page: > Thr490  -  B-Myb (mouse)

Site Information
SQKVVVTtPLHRDKt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452027

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 2 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 4 )
Disease tissue studied:
non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
ES-J1 (stem) ( 2 ) , lung ( 1 ) , U2OS (bone cell) [GR (human)] ( 4 )

Upstream Regulation
Putative in vivo kinases:
CDK2 (human) ( 4 )
Kinases, in vitro:
CDK2 (mouse) ( 3 , 4 )

Downstream Regulation
Effects of modification on B-Myb:
activity, induced ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
non-small cell lung adenocarcinoma ( 1 )

References 

1

Iltzsche F, et al. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene 36, 110-121
27212033   Curated Info

2

Zhou J (2010) CST Curation Set: 9670; Year: 2010; Biosample/Treatment: cell line, ES J1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

3

Müller-Tidow C, et al. (2001) Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood 97, 2091-7
11264176   Curated Info

4

Saville MK, Watson RJ (1998) The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. Oncogene 17, 2679-89
9840932   Curated Info

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