Ser20
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Home > Phosphorylation Site Page: > Ser20  -  ubiquitin (human)

Site Information
ItLEVEPsDtIENVk   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14582508

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , E.coli (bacterial) ( 1 ) , PC9 (pulmonary) ( 3 )

Downstream Regulation
Effects of modification on ubiquitin:
enzymatic activity, induced ( 1 )

References 

1

Huguenin-Dezot N, et al. (2016) Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity. Cell Rep 16, 1180-93
27425610   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info