Ser4573

Site Information
AQKLRDVsAYSKYLT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 14577964

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:	32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 3 ) , 32Dcl3 (myeloid) ( 3 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 2 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Regulatory protein:	FLT3 (mouse) ( 3 )
Treatments:	IL-33 ( 1 )

References
1	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
2	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
3	Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39 19854140 Curated Info