Ser78
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Home > Phosphorylation Site Page: > Ser78  -  p21Cip1 (mouse)

Site Information
GLPKVyLsPGSRSRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14577356

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 5 ) , [32P] bio-synthetic labeling ( 5 ) , flow cytometry ( 8 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 3 , 4 , 6 , 7 , 8 , 9 ) , mass spectrometry (in vitro) ( 5 ) , mutation of modification site ( 8 ) , western blotting ( 5 )
Disease tissue studied:
kidney cancer ( 8 ) , BCC ( 5 )
Relevant cell line - cell type - tissue:
'kidney, tubule' ( 8 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 9 ) , 32Dcl3 (myeloid) ( 9 ) , BaF3 ('B lymphocyte, precursor') [JAK3 (human), transfection] ( 1 ) , HaCaT (keratinocyte) ( 5 ) , HEK293T (epithelial) ( 5 ) , HL-1 (myocyte) [Akt1 (mouse), knockdown, stable lentiviral expression of Akt1 shRNA] ( 4 ) , HL-1 (myocyte) [Akt2 (mouse), knockdown, stable lentiviral expression of Akt2 shRNA] ( 4 ) , HL-1 (myocyte) ( 4 ) , kidney ( 8 ) , macrophage-peritoneum ( 7 ) , RAW 264.7 (macrophage) ( 3 ) , stromal ( 6 )

Upstream Regulation
Kinases, in vitro:
NuaK1 (human) ( 5 )

Downstream Regulation
Effects of modification on p21Cip1:
activity, inhibited ( 8 )
Effects of modification on biological processes:
apoptosis, altered ( 8 )

References 

1

Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia
28852199   Curated Info

2

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

3

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

4

Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45
25162660   Curated Info

5

Esteve-Puig R, et al. (2014) A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21WAF1/CIP1) Degradation. PLoS Genet 10, e1004721
25329316   Curated Info

6

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

7

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

8

Hodeify R, et al. (2011) Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity. Am J Physiol Renal Physiol 300, F1171-9
21325496   Curated Info

9

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

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