Tyr36
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Home > Phosphorylation Site Page: > Tyr36  -  LKB1 (mouse)

Site Information
IDstEVIyQPRRKRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14575494

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Lck (human) ( 1 )
Treatments:
anti-CD3/CD28 ( 1 ) , LckI ( 1 )

Downstream Regulation
Effects of modification on LKB1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
LAT (mouse) ( 1 ) , PLCG1 (mouse) ( 1 )

References 

1

Cao Y, et al. (2011) LKB1 regulates TCR-mediated PLCĪ³1 activation and thymocyte positive selection. EMBO J 30, 2083-93
21487392   Curated Info

2

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info