Ser554
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Home > Phosphorylation Site Page: > Ser554  -  SCN2A (rat)

Site Information
TYEKRFssPHQsLLS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452015

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 , 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , brain ( 1 ) , oocyte [CPEB (mouse)] ( 4 ) , tsA201 (epithelial) ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 4 )
Treatments:
colforsin ( 4 ) , kainic_acid ( 1 )

Downstream Regulation
Effects of modification on SCN2A:
activity, inhibited ( 3 )

References 

1

Baek JH, Rubinstein M, Scheuer T, Trimmer JS (2014) Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures. J Biol Chem 289, 15363-15373
24737319   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Cantrell AR, et al. (2002) Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol Cell Neurosci 21, 63-80
12359152   Curated Info

4

Smith RD, Goldin AL (1997) Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J Neurosci 17, 6086-93
9236220   Curated Info