Ser351
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Home > Phosphorylation Site Page: > Ser351  -  CDC25B (mouse)

Site Information
VQSKRRKsVtPLEEQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452008

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 , 5 ) , mutation of modification site ( 2 , 6 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (mouse) ( 6 ) , AurA (mouse) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 6 ) , cytoskeletal reorganization ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Zhao X, et al. (2015) Successive recruitment of p-CDC25B-Ser351 and p-cyclin B1-Ser123 to centrosomes contributes to the release of mouse oocytes from prophase I arrest. Dev Dyn 244, 110-21
25349079   Curated Info

3

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

6

Feng C, et al. (2007) Involvement of protein kinase B/AKT in early development of mouse fertilized eggs. Biol Reprod 77, 560-8
17554083   Curated Info