Tyr176
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Home > Phosphorylation Site Page: > Tyr176  -  Akt1 (human)

Site Information
EKATGRYyAMKILKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14515900

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Ack (human) ( 2 ) , PIK3CA (human) ( 2 )
Treatments:
heregulin ( 2 ) , insulin ( 2 ) , LY294002 ( 2 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 2 ) , intracellular localization ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , transcription, altered ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 2 )

References 

1

Zhang J, et al. (2015) PDGFR-β-activated ACK1-AKT Signaling Promotes Glioma Tumorigenesis. Int J Cancer 136, 1769-80
25257795   Curated Info

2

Mahajan K, et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One 5, e9646
20333297   Curated Info