Tyr176
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Home > Phosphorylation Site Page: > Tyr176  -  Akt1 (mouse)

Site Information
EKATGRYyAMKILKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14515900

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) [Akt1 (mouse), heterozygous knockout] ( 1 ) , MEF (fibroblast) [Akt2 (mouse), homozygous knockout] ( 1 ) , prostate ( 1 )

Upstream Regulation
Putative in vivo kinases:
Ack (mouse) ( 1 )
Kinases, in vitro:
Ack (mouse) ( 1 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , transcription, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 1 )

References 

1

Mahajan K, et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One 5, e9646
20333297   Curated Info