Lys166

Site Information
VDkIVIQkyHtVNGH SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 14367477
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 )
Disease tissue studied:	colorectal cancer ( 7 ) , colorectal carcinoma ( 7 ) , gastric cancer ( 5 ) , leukemia ( 6 ) , chronic myelogenous leukemia ( 6 ) , lung cancer ( 1 , 2 ) , non-small cell lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 1 ) , Calu-3 (pulmonary) ( 2 ) , HCC827 (pulmonary) ( 2 ) , HCT116 (intestinal) ( 7 ) , HeLa (cervical) ( 3 ) , Jurkat (T lymphocyte) ( 4 ) , K562 (erythroid) ( 6 ) , liver ( 8 ) , lung ( 2 ) , MKN-45 (gastric) ( 5 ) , NCI-H1650 (pulmonary) ( 2 ) , NCI-H1975 (pulmonary) ( 2 ) , NCI-H2106 (pulmonary) ( 2 )

Upstream Regulation
Treatments:	vorinostat ( 1 )

References
1	Wu Q, et al. (2015) Suberoylanilide hydroxamic acid treatment reveals crosstalks among proteome, ubiquitylome and acetylome in non-small cell lung cancer A549 cell line. Sci Rep 5, 9520 25825284 Curated Info
2	Rikova K (2013) CST Curation Set: 20217; Year: 2013; Biosample/Treatment: cell line, H1650, HCC827, H1975, Calu-3, H2106; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
3	Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51 23954790 Curated Info
4	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
5	Rikova K (2012) CST Curation Set: 16030; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
6	Moritz A (2010) CST Curation Set: 9818; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
7	Moritz A (2010) CST Curation Set: 9796; Year: 2010; Biosample/Treatment: cell line, HCT 116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
8	Zhao S, et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-4 20167786 Curated Info