Lys394
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Home > Acetylation Site Page: > Lys394  -  cGAS (human)

Site Information
LNNHGkSkTCCENKE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14366393

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 3 , 4 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
leukemia ( 3 ) , acute myelogenous leukemia ( 3 ) , fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:
bone marrow ( 3 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 3 ) , HT1080 (fibroblast) ( 2 ) , liver ( 4 ) , mononuclear-blood ( 3 ) , THP1 (myeloid) ( 3 )

Upstream Regulation
Regulatory protein:
Tip60 (human) ( 2 )
Treatments:
aspirin ( 3 ) , HT-DNA ( 3 ) , virus infection ( 2 )

Downstream Regulation
Effects of modification on cGAS:
activity, inhibited ( 3 ) , enzymatic activity, inhibited ( 1 ) , protein conformation ( 1 )

References 

1

Guo J, et al. (2021) Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations. Phys Chem Chem Phys 23, 2154-2165
33438687   Curated Info

2

Song ZM, et al. (2020) KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proc Natl Acad Sci U S A
32817552   Curated Info

3

Dai J, et al. (2019) Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell 176, 1447-1460.e14
30799039   Curated Info

4

Zhao S, et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-4
20167786   Curated Info

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