Lys470
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Home > Acetylation Site Page: > Lys470  -  PYGL (mouse)

Site Information
IVkTQVFkDFSELEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14321567

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
hepatocyte-liver ( 2 ) , liver ( 1 ) , muscle cell ( 2 )

Upstream Regulation
Treatments:
glucagon ( 2 ) , glucose ( 2 ) , nicotinamide ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on PYGL:
enzymatic activity, inhibited ( 2 ) , phosphorylation ( 2 )
Induce interaction with:
PPP1CA (mouse) ( 2 )

References 

1

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

2

Zhang T, et al. (2012) Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab 15, 75-87
22225877   Curated Info