Lys220
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Home > Acetylation Site Page: > Lys220  -  PGK1 (human)

Site Information
GGAkVADkIQLINNM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14319999

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 4 ) , modification-specific antibody ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
insulin ( 1 ) , LY294002 ( 1 ) , rapamycin ( 1 ) , trichostatin_A ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on PGK1:
enzymatic activity, inhibited ( 1 )

References 

1

Wang S, et al. (2015) Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol 13, e1002243
26356530   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Zhao S, et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-4
20167786   Curated Info