Ser2844
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser2844  -  RYR1 (mouse)

Site Information
KKKTRkIsQTAQtYD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451818

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 , 4 , 8 , 9 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 , 3 , 6 , 7 ) , western blotting ( 1 , 2 , 3 , 6 , 7 )
Disease tissue studied:
melanoma skin cancer ( 9 )
Relevant cell line - cell type - tissue:
'fat, brown' ( 8 ) , 'muscle, skeletal' ( 2 , 6 , 7 ) , brain [RYR1 (mouse), genetic knockin] ( 5 ) , diaphragm ( 3 ) , lung ( 8 ) , muscle ( 1 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 9 ) , stromal ( 4 )

Upstream Regulation
Regulatory protein:
RYR1 (mouse) ( 6 )
Kinases, in vitro:
PKACA (human) ( 2 )
Treatments:
cAMP_analog ( 1 ) , mechanical ventilation ( 3 ) , PP1 ( 7 ) , S107 ( 3 )

References 

1

Singh DP, et al. (2023) Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proc Natl Acad Sci U S A 120, e2117503120
36649401   Curated Info

2

El-Ajouz S, et al. (2017) Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A. J Physiol 595, 4769-4784
28387457   Curated Info

3

Matecki S, et al. (2016) Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proc Natl Acad Sci U S A 113, 9069-74
27457930   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Liu X, et al. (2012) Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell 150, 1055-67
22939628   Curated Info

6

Barrientos GC, et al. (2012) Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle. J Biol Chem 287, 2863-76
22139840   Curated Info

7

Feng W, et al. (2011) Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Mol Pharmacol 79, 420-31
21156754   Curated Info

8

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

9

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info