Ser117
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Home > Phosphorylation Site Page: > Ser117  -  CREB (rat)

Site Information
DsQEsVDsVtDsQKR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451810

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-pulmonary artery ( 1 ) , UMR106 (bone cell) ( 2 )

Downstream Regulation
Effects of modification on CREB:
protein degradation ( 1 )

References 

1

Garat CV, et al. (2006) Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol 26, 4934-48
16782881   Curated Info

2

Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC (2002) PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology 143, 674-82
11796524   Curated Info