Ser25
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Home > Phosphorylation Site Page: > Ser25  -  14-3-3 eta (human)

Site Information
ERyDDMAsAMKAVTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14159200

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 4 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 4 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , MTV-TM-011 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
LRRC59 (human) ( 1 )
Putative in vivo kinases:
KHK (human) ( 1 )
Kinases, in vitro:
KHK (human) ( 1 )
Treatments:
EGF ( 2 ) , fructose ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on 14-3-3 eta:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 ) , cytoskeletal reorganization ( 1 ) , signaling pathway regulation ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:
Snail2 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 1 )

References 

1

Kim J, et al. (2020) Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. Nat Commun 11, 5436
33116123   Curated Info

2

Huang H, et al. (2016) Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography. Mol Cell Proteomics 15, 3282-3296
27281782   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

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