Ser2843
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser2843  -  RYR1 (rabbit)

Site Information
KKKTRKIsQTAQTYD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451818

In vivo Characterization
Methods used to characterize site in vivo:
back-titration ( 3 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , mutation of modification site ( 2 ) , peptide sequencing ( 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 1 , 3 ) , 293 (epithelial) ( 2 )

Upstream Regulation
Kinases, in vitro:
CAMK1A (human) ( 4 ) , PKACA (cow) ( 4 ) , PKG1 (human) ( 4 )

Downstream Regulation
Effects of modification on RYR1:
molecular association, regulation ( 2 )
Induce interaction with:
CAMK2B (human) ( 2 )

References 

1

Zalk R, et al. (2015) Structure of a mammalian ryanodine receptor. Nature 517, 44-9
25470061   Curated Info

2

Sharma P, et al. (2012) Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS J 279, 3952-64
22913516   Curated Info

3

Varsányi M, Meyer HE (1995) Sarcoplasmic reticular Ca2+ release channel is phosphorylated at serine 2843 in intact rabbit skeletal muscle. Biol Chem Hoppe Seyler 376, 45-9
7612188   Curated Info

4

Suko J, et al. (1993) Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase. Biochim Biophys Acta 1175, 193-206
8380342   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.