Ser107
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Home > Phosphorylation Site Page: > Ser107  -  CREB (mouse)

Site Information
sVDsVTDsQKRREIL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451811

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 4 ) , immunoprecipitation ( 4 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:
liver cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATM (mouse) ( 2 )
Putative in vivo kinases:
ATM (mouse) ( 4 ) , ATR (mouse) ( 4 )
Treatments:
calicheamicin ( 1 ) , differentiation ( 2 ) , hydroxyurea ( 4 ) , ionizing_radiation ( 5 ) , KU-55933 ( 4 ) , siRNA ( 4 ) , UV ( 4 ) , wortmannin ( 5 )

Downstream Regulation
Effects of modification on CREB:
intracellular localization ( 4 )

References 

1

Kim SH, et al. (2021) Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst-attenuation of the cyclic AMP response element binding protein. J Biol Chem 297, 100908
34171357   Curated Info

2

Takagi M, et al. (2015) ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis. Cell Rep
25683718   Curated Info

3

Sheng L, et al. (2012) NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18, 943-9
22581287   Curated Info

4

Shi Y, et al. (2007) Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem 282, 9236-43
17244605   Curated Info

5

Shi Y, et al. (2004) Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A 101, 5898-903
15073328   Curated Info