Ser208
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Home > Phosphorylation Site Page: > Ser208  -  TNNT2 (human)

Site Information
QAQtERKsGKRQtER   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451755

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'blood, plasma' ( 3 ) , E.coli (bacterial) ( 2 ) , myocyte-heart ( 1 )

Upstream Regulation
Putative upstream phosphatases:
PPP2CA (human) ( 1 )
Treatments:
isoproterenol ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
LVR ( 3 ) , MI ( 3 )

References 

1

Kirchhefer U, et al. (2014) Cardiac Function Is Regulated by B56α-mediated Targeting of Protein Phosphatase 2A (PP2A) to Contractile Relevant Substrates. J Biol Chem 289, 33862-73
25320082   Curated Info

2

Liu B, Lopez JJ, Biesiadecki BJ, Davis JP (2014) Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. PLoS One 9, e86279
24466001   Curated Info

3

Dubois E, et al. (2011) Decreased serine207 phosphorylation of troponin T as a biomarker for left ventricular remodelling after myocardial infarction. Eur Heart J 32, 115-23
20418543   Curated Info