Lys364
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Home > Sumoylation Site Page: > Lys364  -  LEDGF (human)

Site Information
AEIKNSLkIDNLDVN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13875714

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoassay ( 1 ) , immunoprecipitation ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , hLECs (epithelial) ( 1 ) , mLEC (epithelial) ( 1 )

Downstream Regulation
Effects of modification on LEDGF:
molecular association, regulation ( 1 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , transcription, inhibited ( 1 , 2 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Ishihara K, et al. (2012) Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response. FEBS J 279, 3048-70
22748127   Curated Info

2

Bueno MT, et al. (2010) SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter. J Mol Biol 399, 221-39
20382164   Curated Info