Tyr816
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Home > Phosphorylation Site Page: > Tyr816  -  TrkB (mouse)

Site Information
LAKASPVyLDILG__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451754

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 , 4 , 11 , 13 ) , immunoprecipitation ( 11 ) , mutation of modification site ( 12 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ) , western blotting ( 2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 )
Disease tissue studied:
Alzheimer's disease ( 11 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 10 ) , 'brain, hippocampus' ( 2 ) , 'brain, striatum' ( 10 ) , 'neuron, cortical' ( 7 , 12 ) , brain ( 3 , 5 , 6 , 9 ) , HEK293T (epithelial) ( 7 ) , HeLa (cervical) ( 12 ) , MG87 (fibroblast) ( 7 ) , neuron ( 3 , 6 ) , neuron-'brain, cerebral cortex' ( 11 ) , neuron-'brain, hippocampus' ( 4 , 13 ) , neuron-spinal cord ( 13 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 13 ) , retinal-retina ( 8 )

Upstream Regulation
Regulatory protein:
BDNF (mouse) ( 11 ) , Calnexin (human) ( 3 ) , CDKL5 (human) ( 2 ) , Tau (human) ( 11 )
Treatments:
L-NPA ( 4 ) , #11a ( 6 ) , 7, 8-Dihydroxyflavone ( 8 ) , BDNF ( 4 , 7 , 12 ) , CF3CN ( 6 ) , CLP290 ( 5 ) , development ( 9 ) , EGF ( 3 ) , estradiol ( 13 ) , HIOC ( 9 ) , ischemia ( 5 , 8 ) , LM22A-4 ( 9 ) , ODQ ( 4 ) , phenobarbital ( 9 ) , SNP ( 4 )

Downstream Regulation
Effects of modification on TrkB:
enzymatic activity, induced ( 12 ) , intracellular localization ( 13 ) , molecular association, regulation ( 4 , 12 ) , phosphorylation ( 6 ) , receptor internalization, induced ( 4 )
Effects of modification on biological processes:
apoptosis, inhibited ( 11 ) , neural plasticity ( 4 , 6 , 10 , 11 , 13 ) , signaling pathway regulation ( 4 , 9 , 11 , 13 ) , transcription, induced ( 6 )
Induce interaction with:
AP2M1 (human) ( 4 ) , PLCG1 (human) ( 12 )

References 

1

Philibert CE, et al. (2024) TrkB receptor interacts with mGlu receptor and mediates antipsychotic-like effects of mGlu receptor activation in the mouse. Sci Adv 10, eadg1679
38277461   Curated Info

2

Zhu ZA, et al. (2023) CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling. Cell Rep 42, 113202
37777961   Curated Info

3

Lüningschrör P, et al. (2023) Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development. Dev Cell 58, 1733-1747.e6
37506696   Curated Info

4

Biojone C, et al. (2023) nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity. Prog Neurobiol 222, 102413
36682419   Curated Info

5

Sullivan BJ, et al. (2021) Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model. Sci Signal 14, eabg2648
34752143   Curated Info

6

Liao J, et al. (2021) Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease. Neuropharmacology 197, 108737
34343610   Curated Info

7

Casarotto PC, et al. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299-1313.e19
33606976   Curated Info

8

Zaitoun IS, et al. (2021) 7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy. PLoS One 16, e0260793
34855884   Curated Info

9

Kipnis PA, Sullivan BJ, Carter BM, Kadam S (2020) TrkB-agonists prevent post-ischemic emergence of refractory neonatal seizures in mice. JCI Insight 5
32427585   Curated Info

10

Becanovic K, et al. (2020) Effects of a novel psychomotor stabilizer, IRL790, on biochemical measures of synaptic markers and neurotransmission. J Pharmacol Exp Ther 374
32358047   Curated Info

11

Xiang J, et al. (2019) Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proc Natl Acad Sci U S A 116, 9094-9102
31004063   Curated Info

12

Harward SC, et al. (2016) Autocrine BDNF-TrkB signalling within a single dendritic spine. Nature 538, 99-103
27680698   Curated Info

13

Spencer-Segal JL, et al. (2011) Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage. J Neurosci 31, 6780-90
21543608   Curated Info