Thr346
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Home > Phosphorylation Site Page: > Thr346  -  PDHK1 (human)

Site Information
APRPRVEtsRAVPLA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13831355

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt2 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 1 ) , Akt2 (human) ( 1 )
Treatments:
hypoxia ( 1 ) , MK-2206 ( 1 )

Downstream Regulation
Effects of modification on PDHK1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )

References 

1

Chae YC, et al. (2016) Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell 30, 257-72
27505672   Curated Info

2

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

3

Li H, et al. (2009) Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells. BMC Cancer 9, 366
19835603   Curated Info