Thr9
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Home > Phosphorylation Site Page: > Thr9  -  PBK (mouse)

Site Information
EGINNFKtPNKSEKR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451735

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 3 , 4 )
Relevant cell line - cell type - tissue:
'neuron, cerebellar granule'-brain ( 4 ) , 32Dcl3 (myeloid) ( 2 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] ( 2 ) , germ cell-testis ( 3 ) , L929 (fibroblast) ( 3 ) , Neuro-2a (neuron) ( 4 ) , P19 (testicular) ( 4 )

Downstream Regulation
Effects of modification on PBK:
enzymatic activity, induced ( 4 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

3

Fujibuchi T, et al. (2005) Expression and phosphorylation of TOPK during spermatogenesis. Dev Growth Differ 47, 637-44
16316408   Curated Info

4

Dougherty JD, et al. (2005) PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci 25, 10773-85
16291951   Curated Info