Ser346
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Home > Phosphorylation Site Page: > Ser346  -  p47phox (mouse)

Site Information
PGRPGPLsTDGTkDN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451727

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
4T1 (breast cell) ( 1 ) , heart ( 2 , 3 ) , myocyte ( 2 ) , myocyte-heart ( 3 ) , neutrophil ( 4 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Regulatory protein:
CAPNS1 (mouse) ( 2 ) , EphA2 (human) ( 4 ) , PKM iso2 (mouse) ( 1 )
Treatments:
C. albicans ( 4 ) , calpain inhibitor-III ( 2 ) , conditioned medium ( 1 ) , IgG ( 4 ) , losartan ( 3 ) , Microgravity ( 2 , 3 ) , PD98059 ( 2 ) , SB203580 ( 2 ) , tail suspension test ( 2 , 3 ) , valsartan ( 3 ) , zymosan ( 4 )

Downstream Regulation
Effects of modification on p47phox:
intracellular localization ( 3 )

References 

1

Hamza A, et al. (2023) Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition. Free Radic Biol Med 208, 614-629
37722568   Curated Info

2

Liang L, et al. (2020) Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways. J Biol Chem
32989050   Curated Info

3

Liang L, et al. (2019) Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47 phosphorylation, NADPH oxidase activation and MuRF1 expression. J Transl Med 17, 279
31438970   Curated Info

4

Swidergall M, et al. (2019) EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection. Cell Rep 28, 423-433.e5
31291578   Curated Info

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