Ser40
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Home > Phosphorylation Site Page: > Ser40  -  NRF2 (rat)

Site Information
SREVFDFsQRQKDYE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450082

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 ) , liver cancer ( 5 )
Relevant cell line - cell type - tissue:
HepG2 (hepatic) ( 5 ) , liver ( 3 , 4 ) , NRK-52E (epithelial) ( 1 ) , PC-12 (chromaffin) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PLK2 (human) ( 1 )
Kinases, in vitro:
PKCA (rat) ( 5 ) , PLK2 (human) ( 1 )
Treatments:
aminoguanidine ( 3 ) , ankaflavin ( 4 ) , aripiprazole ( 2 ) , clozapine ( 2 ) , haloperidol ( 2 ) , methylglyoxal ( 3 , 4 ) , rosiglitazone ( 4 ) , scopoletin ( 3 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on NRF2:
activity, induced ( 5 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 , 5 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, induced ( 5 )
Induce interaction with:
p21Cip1 (human) ( 1 )
Inhibit interaction with:
KEAP1 (mouse) ( 5 )

References 

1

Kim DE, et al. (2022) Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21 signaling in acute kidney injury. Cell Biol Toxicol
35842499   Curated Info

2

Kaneko YS, et al. (2015) Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells. J Neural Transm 122, 757-72
25504008   Curated Info

3

Chang WC, et al. (2015) Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. Molecules 20, 2786-801
25671364   Curated Info

4

Lee BH, et al. (2012) Ankaflavin: a natural novel PPARĪ³ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. Free Radic Biol Med 53, 2008-16
23022408   Curated Info

5

Huang HC, Nguyen T, Pickett CB (2002) Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277, 42769-74
12198130   Curated Info

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