Thr39
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Home > Phosphorylation Site Page: > Thr39  -  Tau iso8 (human)

Site Information
HQDQEGDtDAGLkEs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451639

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mass spectrometry ( 1 ) , phosphopeptide mapping ( 2 )
Disease tissue studied:
Alzheimer's disease ( 1 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
brain ( 1 ) , LAN-5 (neural crest) ( 2 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (cow) ( 2 )

References 

1

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

2

Greenwood JA, et al. (1994) Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor. J Biol Chem 269, 4373-80
8308007   Curated Info