Ser1364
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Home > Phosphorylation Site Page: > Ser1364  -  ITGB4 (human)

Site Information
PSGsQRPsVSDDTGC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451655

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 , 5 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 2 , 4 ) , phosphopeptide mapping ( 4 , 5 ) , western blotting ( 2 , 4 )
Disease tissue studied:
breast cancer ( 1 ) , breast ductal carcinoma ( 1 ) , PA-JEB ( 2 )
Relevant cell line - cell type - tissue:
804G (epithelial) ( 3 ) , breast ( 1 ) , COS (fibroblast) [ITGA6 (human)] ( 5 ) , COS (fibroblast) ( 2 , 4 ) , HaCaT (keratinocyte) ( 5 ) , PA-JEB (keratinocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
p90RSK (human) ( 2 ) , PKACA (human) ( 4 )
Kinases, in vitro:
PKACA (human) ( 4 ) , PKCA (human) ( 5 )
Treatments:
BI-D1870 ( 2 ) , colforsin ( 2 , 4 ) , EGF ( 2 , 4 , 5 ) , Go_6983 ( 2 ) , IBMX ( 2 , 4 ) , ischemia ( 1 ) , PD98059 ( 2 ) , phorbol_ester ( 2 ) , SB203580 ( 2 ) , sorbitol ( 2 ) , U0126 ( 2 )

Downstream Regulation
Effects of modification on ITGB4:
molecular association, regulation ( 2 , 4 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Inhibit interaction with:
Plectin-1 (human) ( 2 , 4 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Frijns E, et al. (2010) EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem 285, 37650-62
20870721   Curated Info

3

Germain EC, Santos TM, Rabinovitz I (2009) Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell 20, 56-67
19005215   Curated Info

4

Wilhelmsen K, et al. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell 18, 3512-22
17615294   Curated Info

5

Rabinovitz I, Tsomo L, Mercurio AM (2004) Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol 24, 4351-60
15121854   Curated Info

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