Tyr388
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Home > Phosphorylation Site Page: > Tyr388  -  HS1 (mouse)

Site Information
EPEtEPDyEDVGELD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451635

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
lymphoma ( 3 ) , B cell lymphoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
Fes (mouse) ( 2 )
Treatments:
anti-IgM ( 3 )

Downstream Regulation
Effects of modification on HS1:
intracellular localization ( 3 ) , molecular association, regulation ( 1 )
Induce interaction with:
ITK (human) ( 1 )

References 

1

Carrizosa E, et al. (2009) Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading. J Immunol 183, 7352-61
19917685   Curated Info

2

McPherson VA, et al. (2009) Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. Mol Cell Biol 29, 389-401
19001085   Curated Info

3

Hao JJ, Carey GB, Zhan X (2004) Syk-mediated tyrosine phosphorylation is required for the association of hematopoietic lineage cell-specific protein 1 with lipid rafts and B cell antigen receptor signalosome complex. J Biol Chem 279, 33413-20
15166239   Curated Info