Ser515
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Home > Phosphorylation Site Page: > Ser515  -  ADRA1D (human)

Site Information
TQLRAKVssLsHKIR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1346843001

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , Flp-In T-Rex-293 (epithelial) ( 2 )

Upstream Regulation
Treatments:
norepinephrine ( 1 , 2 ) , phorbol_ester ( 1 , 2 )

Downstream Regulation
Effects of modification on ADRA1D:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , receptor internalization, altered ( 2 ) , receptor internalization, induced ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 2 )
Induce interaction with:
ARRB1 (human) ( 1 )

References 

1

Carmona-Rosas G, et al. (2019) Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α-adrenergic receptor subcellular localization and signaling. Cell Signal 53, 374-389
30419287   Curated Info

2

Alfonzo-Méndez MA, et al. (2018) Different phosphorylation patterns regulate α-adrenoceptor signaling and desensitization. Biochim Biophys Acta 1865, 842-854
29551601   Curated Info

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