Thr293
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Home > Phosphorylation Site Page: > Thr293  -  LARS (human)

Site Information
NIFLVAAtLRPETMF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1345849602

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , SH-SY5Y (neural crest) ( 1 ) , SN4741 (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
LRRK2 (human) ( 1 )
Kinases, in vitro:
LRRK2 (human) ( 1 )
Treatments:
GSK2578215A ( 1 )

Downstream Regulation
Effects of modification on LARS:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, inhibited ( 1 )
Induce interaction with:
LC3B (human) ( 1 )

References 

1

Ho DH, et al. (2018) LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase. Cell Biochem Funct 36, 431-442
30411383   Curated Info