Ser308
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Home > Phosphorylation Site Page: > Ser308  -  BRCA1 (human)

Site Information
KAEFCNKskQPGLAR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451604

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 , 2 )
Kinases, in vitro:
AurA (human) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Ertych N, et al. (2016) CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. Proc Natl Acad Sci U S A 113, 1817-22
26831064   Curated Info

2

Ouchi M, et al. (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 279, 19643-8
14990569   Curated Info