Ser525
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Home > Phosphorylation Site Page: > Ser525  -  SCN5A (human)

Site Information
TsMKPRssrGsIFtF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451568

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 1 )
Treatments:
AZD1152 ( 2 ) , ZM447439 ( 2 )

Downstream Regulation
Effects of modification on SCN5A:
activity, induced ( 4 )

References 

1

Beltran-Alvarez P, et al. (2015) Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Amino Acids 47, 429-34
25501501   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

3

Possemato A (2007) CST Curation Set: 2928; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Zhou J, et al. (2002) Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current. Circ Res 91, 540-6
12242273   Curated Info