Thr6
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Home > Phosphorylation Site Page: > Thr6  -  H3 (human)

Site Information
__ArtkQtArkstGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13321500

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 4 ) , immunoprecipitation ( 1 , 3 , 4 ) , mass spectrometry ( 1 , 5 ) , modification-specific antibody ( 3 , 4 ) , phospho-antibody ( 1 , 3 , 4 , 5 ) , western blotting ( 1 , 4 , 5 )
Disease tissue studied:
prostate cancer ( 3 , 4 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 4 ) , HeLa (cervical) ( 4 , 5 ) , LNCaP (prostate cell) ( 3 , 4 ) , prostate ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 2 ) , PKCB (human) ( 4 )
Kinases, in vitro:
ChaK2 (human) ( 1 ) , PKCB (human) ( 4 )
Treatments:
androstanolone ( 3 ) , arcyriarubin_A ( 4 ) , bisindolylmaleimide ( 3 ) , siRNA ( 4 )

Downstream Regulation
Effects of modification on H3:
methylation ( 4 ) , molecular association, regulation ( 5 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , transcription, induced ( 3 , 4 )
Inhibit interaction with:
AIRE (human) ( 5 ) , ING2 (human) ( 5 ) , PHF21A (human) ( 5 ) , RAG2 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma multiforme ( 2 ) , prostate cancer ( 4 )

References 

1

Krapivinsky G, et al. (2017) Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A 114, E7092-E7100
28784805   Curated Info

2

Pacaud R, et al. (2015) Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy. Theranostics 5, 12-22
25553095   Curated Info

3

Cai C, et al. (2014) Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity. Cell Rep 9, 1618-27
25482560   Curated Info

4

Metzger E, et al. (2010) Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464, 792-6
20228790   Curated Info

5

Garske AL, et al. (2010) Combinatorial profiling of chromatin binding modules reveals multisite discrimination. Nat Chem Biol 6, 283-90
20190764   Curated Info

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