Ser69
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Home > Phosphorylation Site Page: > Ser69  -  FCER1G (human)

Site Information
DGVytGLstRNQEty   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13310016

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , hepatocellular carcinoma, surrounding tissue ( 7 ) , lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 6 ) , ovarian cancer ( 3 ) , pancreatic ductal adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 5 ) , breast ( 2 ) , hepatocyte-liver ( 7 ) , leukocyte-blood ( 8 ) , liver ( 4 ) , lung ( 6 ) , ovary ( 3 ) , RBL-2H3 (basophil) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 1 ) , PKCB (human) ( 1 ) , PKCD (human) ( 1 )

Downstream Regulation
Effects of modification on FCER1G:
molecular association, regulation ( 1 )
Inhibit interaction with:
Syk (human) ( 1 )

References 

1

Shah S, et al. (2017) Regulation of FcRγ function by site-specific serine phosphorylation. J Leukoc Biol 101, 421-428
27630214   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

5

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

6

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

7

Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9
20166139   Curated Info

8

Raijmakers R, et al. (2010) Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem 82, 824-32
20058876   Curated Info