Ser459
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Home > Phosphorylation Site Page: > Ser459  -  Fe65 (mouse)

Site Information
VWGVGRDsGSNRDFA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13309858

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , retina ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCI (human) ( 1 )
Kinases, in vitro:
PKCI (mouse) ( 1 )
Treatments:
insulin ( 1 ) , siRNA ( 1 ) , t-ACPD ( 1 )

Downstream Regulation
Effects of modification on Fe65:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
ARF6 (human) ( 1 )

References 

1

Chau DD, et al. (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling. FASEB J 36, e22594
36250347   Curated Info

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