Ser293
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Home > Phosphorylation Site Page: > Ser293  -  IkB-alpha (mouse)

Site Information
EESYDTEsEFTEDEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451525

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phosphoamino acid analysis ( 1 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:
lymphoma ( 1 ) , B cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
WEHI-231 (B lymphocyte) ( 1 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (mouse) ( 1 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein degradation ( 1 )

References 

1

Schwarz EM, Van Antwerp D, Verma IM (1996) Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha. Mol Cell Biol 16, 3554-9
8668171   Curated Info

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