Tyr365
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Home > Phosphorylation Site Page: > Tyr365  -  LKB1 (mouse)

Site Information
DIEDGIIytQDFTVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13258701

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 3 ) , Lck (human) ( 2 )
Kinases, in vitro:
Fyn (human) ( 1 , 3 )
Treatments:
anti-CD3/CD28 ( 2 ) , LckI ( 2 ) , SU6656 ( 3 )

Downstream Regulation
Effects of modification on LKB1:
intracellular localization ( 2 , 3 ) , molecular association, regulation ( 1 , 2 ) , phosphorylation ( 1 , 3 )
Effects of modification on biological processes:
cell differentiation, induced ( 2 ) , signaling pathway regulation ( 2 )
Induce interaction with:
Fyn (human) ( 1 ) , LAT (mouse) ( 2 ) , PLCG1 (mouse) ( 2 )

References 

1

Yamada E, Bastie CC (2014) Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase. PLoS One 9, e89604
24586906   Curated Info

2

Cao Y, et al. (2011) LKB1 regulates TCR-mediated PLCĪ³1 activation and thymocyte positive selection. EMBO J 30, 2083-93
21487392   Curated Info

3

Yamada E, et al. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 11, 113-24
20142099   Curated Info