Tyr365

Site Information
DIEDGIIytQDFTVP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 13258701

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:	leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:	3T3-L1 (fibroblast) ( 3 ) , C2C12 (myoblast) ( 3 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , thymocyte ( 2 )

Downstream Regulation
Effects of modification on LKB1:	intracellular localization ( 2 , 3 ) , molecular association, regulation ( 1 , 2 ) , phosphorylation ( 1 , 3 )
Effects of modification on biological processes:	cell differentiation, induced ( 2 ) , signaling pathway regulation ( 2 )
Induce interaction with:	Fyn (human) ( 1 ) , LAT (mouse) ( 2 ) , PLCG1 (mouse) ( 2 )

References
1	Yamada E, Bastie CC (2014) Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase. PLoS One 9, e89604 24586906 Curated Info
2	Cao Y, et al. (2011) LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection. EMBO J 30, 2083-93 21487392 Curated Info
3	Yamada E, et al. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 11, 113-24 20142099 Curated Info