Ser528
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser528  -  NFkB-p65 (rat)

Site Information
SGLPNGLsGDEDFSs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447799

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 , 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , 'muscle, smooth'-thoracic aorta ( 3 ) , 'neuron, hippocampal, CA1 pyramidal' ( 2 ) , 'neuron, hippocampal, CA3 pyramidal' ( 2 ) , astrocyte ( 1 ) , Dentate granule cell ( 2 ) , Dentate hilar neuron ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 1 )
Treatments:
3CAI ( 1 ) , NAC ( 1 ) , status epilepticus ( 2 ) , TMCB ( 1 ) , TNF ( 3 )

Downstream Regulation
Effects of modification on biological processes:
autophagy, induced ( 1 )

References 

1

Kim JE, et al. (2023) Distinct Roles of CK2- and AKT-Mediated NF-κB Phosphorylations in Clasmatodendrosis (Autophagic Astroglial Death) within the Hippocampus of Chronic Epilepsy Rats. Antioxidants (Basel) 12
37237886   Curated Info

2

Ryu HJ, et al. (2011) ReLA/P65-serine 536 nuclear factor-kappa B phosphorylation is related to vulnerability to status epilepticus in the rat hippocampus. Neuroscience 187, 93-102
21550382   Curated Info

3

Xing D, et al. (2011) O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One 6, e24021
21904602   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.