Ser276
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Home > Phosphorylation Site Page: > Ser276  -  NFkB-p65 (rat)

Site Information
SMQLRRPsDRELSEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447798

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 4 , 5 ) , western blotting ( 1 , 4 , 5 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , COS (fibroblast) ( 5 ) , DP5-2 ( 5 ) , Schwann ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 4 , 5 )
Treatments:
cAMP_analog ( 4 ) , cholinergic_lesion ( 1 ) , colforsin ( 4 ) , H-89 ( 4 , 5 ) , leptin ( 6 ) , siRNA ( 5 ) , status epilepticus ( 3 ) , virus infection ( 5 )

Downstream Regulation
Effects of modification on biological processes:
cell differentiation, altered ( 4 ) , transcription, induced ( 4 )

References 

1

Lim CS, et al. (2011) Increased interactions between PKA and NF-κB signaling in the hippocampus following loss of cholinergic input. Neuroscience 192, 485-93
21723926   Curated Info

2

Flinder LI, et al. (2011) EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase. J Cell Physiol 226, 2267-78
21660950   Curated Info

3

Ryu HJ, et al. (2011) ReLA/P65-serine 536 nuclear factor-kappa B phosphorylation is related to vulnerability to status epilepticus in the rat hippocampus. Neuroscience 187, 93-102
21550382   Curated Info

4

Yoon C, Korade Z, Carter BD (2008) Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. J Neurosci 28, 3738-46
18385332   Curated Info

5

Guan H, Jiao J, Ricciardi RP (2008) Tumorigenic adenovirus type 12 E1A inhibits phosphorylation of NF-kappaB by PKAc, causing loss of DNA binding and transactivation. J Virol 82, 40-8
17959673   Curated Info

6

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info