Ser720

Site Information
TSENPTQsPWCSQYR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 13204438

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 , 4 , 5 ) , mutation of modification site ( 2 , 5 ) , western blotting ( 2 )
Disease tissue studied:	cervical cancer ( 5 ) , cervical adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 , 2 , 3 ) , HeLa S3 (cervical) ( 5 ) , HeLa_BI (cervical) ( 4 ) , HeLa_Hesp (cervical) ( 4 )

Upstream Regulation
Treatments:	AZ3146 ( 2 ) , BI2536 ( 2 ) , SP600125 ( 2 ) , ZM447439 ( 2 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Tipton AR, et al. (2013) Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. J Biol Chem 288, 35149-58 24151075 Curated Info
3	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
4	Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12 22067460 Curated Info
5	Elowe S, et al. (2010) Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1. J Cell Sci 123, 84-94 20016069 Curated Info