Ser362
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Home > Phosphorylation Site Page: > Ser362  -  TTK (human)

Site Information
TLKNktEssLLAkLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13194902

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 , 2 ) , mutation of modification site ( 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
SW480 (intestinal) ( 2 )

Upstream Regulation
Kinases, in vitro:
PLK1 (human) ( 1 ) , TTK (human) ( 2 )

Downstream Regulation
Effects of modification on TTK:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 )

References 

1

von Schubert C, et al. (2015) Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells. Cell Rep 12, 66-78
26119734   Curated Info

2

Xu Q, et al. (2009) Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell 20, 10-20
18923149   Curated Info

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